zlatiah

Oh boy it’s my time to shine!

I’m working in aging right now. Heard of Dr. David Sinclair since he was the corresponding author on a paper I was curious about… So this is what his lab is doing.

Two important disclaimers:

• Success in cellular research rarely translates to something viable in the clinic. A lot of chemicals don’t behave the same way in cells as in actual animals or humans. Heck, a good number of phase 2 drugs even fail, and these haven’t even made it into phase 1… so I wouldn’t be too optimistic about them.
• The journal Aging is not the most prestigious journal especially for someone working at Harvard Medical School (HMS) to be honest. I’d be more excited if this was published in Nature Aging or Nature Communications or something. If this ever gets published in New England Journal of Medicine (a very prestigious journal only for clinical studies) then we have some news.

The link between cell senescence and aging is something actively being studied tho.

And, if anyone is curious about this topic: I’m also very actively following Dr. Vadim Gladyshev who is also from HMS and is working in aging, I believe he is doing some wet lab-biology on a similar area as well. Feels like his research is sometimes a bit ahead of his time but I think his work has great potential.

mailbox.org and skiff are „too expensive“ with 3€/month.

Ah… I do use mailbox.org and I’ve self-hosted with docker-mailserver before.

I agree, selfhosting mail is a really big pain, and at least where I live most ISPs don’t open the ports necessary for mailservers, so I had to spin up my own server & it was more expensive than just using a mail provider. Could potentially be the cheapest option if I could host it from home & just use a RasPi or something

I’m happy with mailbox.org; the Standard Tier price is 2.50 Euro/mo if paid in full if that helps. Probably not the cheapest option especially since it’s not unlimited, but they do allow domain matches at Standard tier or above, and there are other goodies like calendar/video conferencing/cloud storage & stuff.

Interesting, I did drive for Uber Eats during the pandemic a bit…

I guess the main “backlash” is because these few companies have to pay minimum wage now? Drivers are gig workers so have been treated as independent contractors so far: a.k.a. no employee benefits, absolutely no minimum wage… The flexibility might sound alright to some on first glance, but the more you think about it the worst it gets. And yeah these companies basically made money by giving the false pretense that you can have a flexible work schedule but then squeeze profits out from both ends

So to get back to this… I guess these companies are arguing about this law not just because they are greedy for a few extra bucks, but because mandating them to pay minimum wage might straight-up bankrupt their businesses? I don’t mind tho… Uber got to where it is today by being a loss leader & drove out the cab companies. Might as well let 'em taste a bit of their own medicine for all the shitty gig economy they brought to us

Out of curiosity… Anyone use the Steam Deck as a computer beyond just gaming? I don’t play games that much but I’d love a decent spec portable computer that I can also use to play video games, the price is quite generous given what its specs look like so…