I think the only reasonable way to do that would be using AI since the sponsors are placed randomly throughout usually. Unless you listen to a specific podcast and they do same length of sponsor in same time slot every video you could automate something that cuts it out.
I’m sure there would be a way to create a script that puts the commands that you’d like in for a given url. Also haven’t used yt-dlp, it’s nice that they have sponsorblock built in.
This is very interesting, I’ve always wondered how WINE/Proton all works.
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https://www.youtube.com/watch?v=gVuabEckMMA
(From https://www.reddit.com/r/Piracy/comments/kqw0si/guide_on_how_to_easly_run_pirated_games_on_linux/?rdt=44586)
If Lutris is having issues, you may have better luck using Bottles, also trying the non flatpak version if you are currently using flatpak.